Cell cycle checkpoint-related genes (CCCRGs) are implicated in the development and progression of hepatocellular carcinoma ...
GMCL1-dependent degradation of 53BP1 suppresses mitotic surveillance, tuning p53 activation thresholds that govern cell fate decisions and cellular responses after mitosis.
Understanding why cancer cells rely on specific genes is critical for designing effective targeted therapies. A new study ...
By editing thousands of genes in mouse stem cells, the scientists identified a list of over 300 that are crucial for neural differentiation.
Despite the immense amount of genetic material present in each cell, around 3 billion base pairs in humans, this material ...
A recent study published in the journal Frontiers in Endocrinology investigated the role of the short-chain dehydrogenase/reductase 42E member 1 (SDR42E1) enzyme in regulating sterol metabolism and ...
Researchers at The Institute of Cancer Research, London identified the CIP2A–TOPBP1 complex as a master regulator of DNA repair during mitosis, coordinating backup pathways that protect chromosomes ...
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