A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most powerful genetic "on switches" in cancer cells, called super-enhancers, drive ...

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave.

Researchers at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy found that ...

A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how our bodies sense and respond to stress. The findings of the UC ...

Lysosomes are membrane-bound organelles whose acidic lumen (pH 4.5–5.0) is required for degradation. This luminal acidity is ...

A new LUMC study has changed our understanding of how cells work. Researchers have discovered that the CFAP20 protein acts as ...

A protein found in our cells has emerged as a secret weapon against biological aging, acting like a glue to repair damaged DNA and ward off neurological degeneration including that seen in motor ...

Scientists have recently been learning more about the importance of small bits of circular genetic material known as extrachromosomal DNA (ecDNA). These little circles of DNA can hitch a ride with ...

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic tangles overwhelm normal repair pathways, cells flip on a fast but error-prone ...

G4 and R-loop signals at the indicated genomic locus. Both G4s and R-loops accumulate in cells where the resolution of G4 knots is defective (red). Not all DNA looks like the familiar twisted ladder.