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Structure-based development of potent and selective type-II kinase inhibitors of RIPK1

A publication from Acta Pharmaceutica Sinica B discusses the structure-based development of potent and selective type-II kinase inhibitors of RIPK1. Receptor-interacting serine/threonine-protein ...
Science Daily

After more than 20 years, scientists have solved the full-length structure of a Janus Kinase

More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers. For more than 20 ...
EurekAlert!

Revealing an invisible kinase state that accounts for vital biological function

(MEMPHIS, Tenn. – December 18, 2025) Scientists at St. Jude Children’s Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows ...
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A short-lived kinase state that's essential for normal cell migration and T-cell function

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its ...
EurekAlert!

Cryo-EM structure of ubiquitous mitochondrial creatine kinase (IMAGE)

Cryo-EM structure of ubiquitous mitochondrial creatine kinase (IMAGE) Sanford Burnham Prebys Caption Scientists at Sanford Burnham Prebys and the Mayo Clinic used cryogenic electron microscopy to ...