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Speedball, powerball, or over and under[1] is the polydrug mixture of a stimulant with a depressant, usually an opioid. The most well-known mixture used for recreational drug use is that of cocaine and …

Dec 2, 2024 · A speedball is a combination of heroin and cocaine taken intravenously. It can cause harmful effects and requires treatment to manage addiction.

Jan 6, 2026 · A speedball is a dangerous mix of a stimulant (most often cocaine) and a depressant (most often heroin or another opioid). This combination is especially risky because the opposing …

Oct 19, 2025 · A speedball is a dangerous combination of a stimulant drug, such as cocaine, and a depressant drug, most commonly heroin. The two drugs have opposite effects on the body, which …

A speedball is a combination of heroin and cocaine that is usually injected, snorted or smoked. The high produced by the stimulant effect of cocaine combined with the depressant effect of heroin is …

Sep 19, 2024 · When a speedball is injected, the body is forced to process the two types of drugs simultaneously. Taking heroin and cocaine together causes a “push-pull” reaction in the body.

Sep 10, 2025 · A speedball is a combination of 2 strong and potentially lethal substances: heroin and cocaine. This deadly mix of uppers and downers is often prepared by mixing powdered cocaine, a …

Nov 7, 2024 · What Is a Speedball? A speedball is a form of polydrug abuse that refers to the combination of stimulant and depressant drugs. This drug combination typically involves …

Aug 2, 2024 · What Is a Speedball? The term speedball is commonly applied to any combination of two different drug types: an opioid and a stimulant. 2 The classic “speedball” is specifically heroin and …